Sequential functional imaging with technetium-99m hexakis-2-meth oxyisobutylisonitrile and indium-111 octreotide: can we predict the response to chemotherapy in small cell lung cancer?
Identifieur interne : 000094 ( Main/Exploration ); précédent : 000093; suivant : 000095Sequential functional imaging with technetium-99m hexakis-2-meth oxyisobutylisonitrile and indium-111 octreotide: can we predict the response to chemotherapy in small cell lung cancer?
Auteurs : RBID : ISTEX:259_1995_Article_BF00838949.pdfEnglish descriptors
- KwdEn :
Abstract
A case of small cell lung carcinoma (SCLC) demonstrating uptake on functional indium-111 octreotide scintigraphy is presented. Technetium-99m hexakis-2-methoxyisobutylisonitrile (MIBI) scintigraphy clearly delineated an absence of radionuclide uptake at the tumour site. This suggested the presence of multidrug resistance-mediated P glycoprotein (Pgp) on tumour cells, which recognizes certain chemotherapeutic agents as well as MIBI as a substrate and avoids radionuclide concentration. Following three courses of chemotherapy, the patient failed to improve and eventually died. This case demonstrates the importance of functional images, which have the potential to predict the outcome in response to chemotherapy.
DOI: 10.1007/BF00838949
Links toward previous steps (curation, corpus...)
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title>Sequential functional imaging with technetium-99m hexakis-2-meth oxyisobutylisonitrile and indium-111 octreotide: can we predict the response to chemotherapy in small cell lung cancer?</title><author><name>J. L. Moretti</name><affiliation wicri:level="3"><mods:affiliation>Hopital Avicenne CHU Bobigny, Universite Paris XIII, 125, route de Stalingrad, F-93009, Bobigny, France</mods:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Hopital Avicenne CHU Bobigny, Universite Paris XIII, 125, route de Stalingrad, F-93009, Bobigny</wicri:regionArea><placeName><region type="region" nuts="2">Île-de-France</region><settlement type="city">Bobigny</settlement></placeName></affiliation></author><author><name>M. Caglar</name><affiliation wicri:level="3"><mods:affiliation>Hopital Avicenne CHU Bobigny, Universite Paris XIII, 125, route de Stalingrad, F-93009, Bobigny, France</mods:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Hopital Avicenne CHU Bobigny, Universite Paris XIII, 125, route de Stalingrad, F-93009, Bobigny</wicri:regionArea><placeName><region type="region" nuts="2">Île-de-France</region><settlement type="city">Bobigny</settlement></placeName></affiliation></author><author><name>C. Boaziz</name><affiliation wicri:level="3"><mods:affiliation>Hopital Avicenne CHU Bobigny, Universite Paris XIII, 125, route de Stalingrad, F-93009, Bobigny, France</mods:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Hopital Avicenne CHU Bobigny, Universite Paris XIII, 125, route de Stalingrad, F-93009, Bobigny</wicri:regionArea><placeName><region type="region" nuts="2">Île-de-France</region><settlement type="city">Bobigny</settlement></placeName></affiliation></author><author><name>N. Caillat-Vigneron</name><affiliation wicri:level="3"><mods:affiliation>Hopital Avicenne CHU Bobigny, Universite Paris XIII, 125, route de Stalingrad, F-93009, Bobigny, France</mods:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Hopital Avicenne CHU Bobigny, Universite Paris XIII, 125, route de Stalingrad, F-93009, Bobigny</wicri:regionArea><placeName><region type="region" nuts="2">Île-de-France</region><settlement type="city">Bobigny</settlement></placeName></affiliation></author><author><name>J. F. Morere</name><affiliation wicri:level="3"><mods:affiliation>Hopital Avicenne CHU Bobigny, Universite Paris XIII, 125, route de Stalingrad, F-93009, Bobigny, France</mods:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Hopital Avicenne CHU Bobigny, Universite Paris XIII, 125, route de Stalingrad, F-93009, Bobigny</wicri:regionArea><placeName><region type="region" nuts="2">Île-de-France</region><settlement type="city">Bobigny</settlement></placeName></affiliation></author></titleStmt><publicationStmt><idno type="RBID">ISTEX:259_1995_Article_BF00838949.pdf</idno><date when="1995">1995</date><idno type="doi">10.1007/BF00838949</idno><idno type="wicri:Area/Main/Corpus">000200</idno><idno type="wicri:Area/Main/Curation">000200</idno><idno type="wicri:Area/Main/Exploration">000094</idno></publicationStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Indium-111 octreotide</term><term>Multidrug resistance</term><term>Small cell lung cancer</term><term>Technetium-99m hexakis-2-methoxyisobutylisonitrile</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="eng">A case of small cell lung carcinoma (SCLC) demonstrating uptake on functional indium-111 octreotide scintigraphy is presented. Technetium-99m hexakis-2-methoxyisobutylisonitrile (MIBI) scintigraphy clearly delineated an absence of radionuclide uptake at the tumour site. This suggested the presence of multidrug resistance-mediated P glycoprotein (Pgp) on tumour cells, which recognizes certain chemotherapeutic agents as well as MIBI as a substrate and avoids radionuclide concentration. Following three courses of chemotherapy, the patient failed to improve and eventually died. This case demonstrates the importance of functional images, which have the potential to predict the outcome in response to chemotherapy.</div></front></TEI><mods xsi:schemaLocation="http://www.loc.gov/mods/v3 file:///applis/istex/home/loadistex/home/etc/xsd/mods.xsd" version="3.4" istexId="2229e138b769c5b63c9aa4562efa6865fd28a74f"><titleInfo lang="eng"><title>Sequential functional imaging with technetium-99m hexakis-2-meth oxyisobutylisonitrile and indium-111 octreotide: can we predict the response to chemotherapy in small cell lung cancer?</title></titleInfo><name type="personal"><namePart type="given">J. L.</namePart><namePart type="family">Moretti</namePart><role><roleTerm type="text">author</roleTerm></role><affiliation>Hopital Avicenne CHU Bobigny, Universite Paris XIII, 125, route de Stalingrad, F-93009, Bobigny, France</affiliation></name><name type="personal"><namePart type="given">M.</namePart><namePart type="family">Caglar</namePart><role><roleTerm type="text">author</roleTerm></role><affiliation>Hopital Avicenne CHU Bobigny, Universite Paris XIII, 125, route de Stalingrad, F-93009, Bobigny, France</affiliation></name><name type="personal"><namePart type="given">C.</namePart><namePart type="family">Boaziz</namePart><role><roleTerm type="text">author</roleTerm></role><affiliation>Hopital Avicenne CHU Bobigny, Universite Paris XIII, 125, route de Stalingrad, F-93009, Bobigny, France</affiliation></name><name type="personal"><namePart type="given">N.</namePart><namePart type="family">Caillat-Vigneron</namePart><role><roleTerm type="text">author</roleTerm></role><affiliation>Hopital Avicenne CHU Bobigny, Universite Paris XIII, 125, route de Stalingrad, F-93009, Bobigny, France</affiliation></name><name type="personal"><namePart type="given">J. F.</namePart><namePart type="family">Morere</namePart><role><roleTerm type="text">author</roleTerm></role><affiliation>Hopital Avicenne CHU Bobigny, Universite Paris XIII, 125, route de Stalingrad, F-93009, Bobigny, France</affiliation></name><typeOfResource>text</typeOfResource><genre>Case Report</genre><genre>Brief Communication</genre><originInfo><publisher>Springer-Verlag, Berlin/Heidelberg</publisher><dateCreated encoding="w3cdtf">1994-08-05</dateCreated><dateValid encoding="w3cdtf">2004-12-01</dateValid><copyrightDate encoding="w3cdtf">1995</copyrightDate></originInfo><language><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType></physicalDescription><abstract lang="eng">A case of small cell lung carcinoma (SCLC) demonstrating uptake on functional indium-111 octreotide scintigraphy is presented. Technetium-99m hexakis-2-methoxyisobutylisonitrile (MIBI) scintigraphy clearly delineated an absence of radionuclide uptake at the tumour site. This suggested the presence of multidrug resistance-mediated P glycoprotein (Pgp) on tumour cells, which recognizes certain chemotherapeutic agents as well as MIBI as a substrate and avoids radionuclide concentration. Following three courses of chemotherapy, the patient failed to improve and eventually died. This case demonstrates the importance of functional images, which have the potential to predict the outcome in response to chemotherapy.</abstract><subject lang="eng"><genre>Key words</genre><topic>Technetium-99m hexakis-2-methoxyisobutylisonitrile</topic><topic>Indium-111 octreotide</topic><topic>Small cell lung cancer</topic><topic>Multidrug resistance</topic></subject><relatedItem type="series"><titleInfo type="abbreviated"><title>Eur J Nucl Med</title></titleInfo><titleInfo><title>European Journal of Nuclear Medicine</title><partNumber>Year: 1995</partNumber><partNumber>Volume: 22</partNumber><partNumber>Number: 2</partNumber></titleInfo><genre>Archive Journal</genre><originInfo><dateIssued encoding="w3cdtf">1995-02-01</dateIssued><copyrightDate encoding="w3cdtf">1995</copyrightDate></originInfo><subject usage="primary"><topic>Medicine & Public Health</topic><topic>Imaging / Radiology</topic><topic>Nuclear Medicine</topic></subject><identifier type="issn">0340-6997</identifier><identifier type="issn">Electronic: 1619-7089</identifier><identifier type="matrixNumber">259</identifier><identifier type="local">IssueArticleCount: 18</identifier><recordInfo><recordOrigin>Springer-Verlag, 1995</recordOrigin></recordInfo></relatedItem><identifier type="doi">10.1007/BF00838949</identifier><identifier type="matrixNumber">Art13</identifier><identifier type="local">BF00838949</identifier><accessCondition type="use and reproduction">MetadataGrant: OpenAccess</accessCondition><accessCondition type="use and reproduction">AbstractGrant: OpenAccess</accessCondition><accessCondition type="restriction on access">BodyPDFGrant: Restricted</accessCondition><accessCondition type="restriction on access">BodyHTMLGrant: Restricted</accessCondition><accessCondition type="restriction on access">BibliographyGrant: Restricted</accessCondition><accessCondition type="restriction on access">ESMGrant: Restricted</accessCondition><part><extent unit="pages"><start>177</start><end>180</end></extent></part><recordInfo><recordOrigin>Springer-Verlag, 1995</recordOrigin><recordIdentifier>259_1995_Article_BF00838949.pdf</recordIdentifier></recordInfo></mods></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=IndiumV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000094 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 000094 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= *** parameter Area/wikiCode missing ***
|area= IndiumV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= ISTEX:259_1995_Article_BF00838949.pdf
|texte= Sequential functional imaging with technetium-99m hexakis-2-meth oxyisobutylisonitrile and indium-111 octreotide: can we predict the response to chemotherapy in small cell lung cancer?
}}
| This area was generated with Dilib version V0.5.81. |  |